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The National Pediatric Cancer Foundation (NPCF) is a nonprofit organization dedicated to funding and developing novel research and clinical trials to find less toxic, more effective treatments for childhood cancer. Our purpose is to reduce the side effects of current treatments, improve survival rates, and ultimately eliminate childhood cancer. NPCF is a nonprofit organization under section 501(c)(3) of the Internal Revenue Code. At the National Pediatric Cancer Foundation, we are aggressively pursuing measurable change in how pediatric cancer research is approached and funded through our collaborative research consortium, the Sunshine Project. The Sunshine Project’s one-of-a-kind research model focuses on translational studies and phase 0, 1, and 2 clinical trials that address a multitude of different pediatric cancers. Our innovative approach capitalizes on the strengths of researchers from various scientific fields throughout the country, streamlining the protocol development process to deliver more personalized medicine to children with cancer. This utilization of scientific and philanthropic partnerships allows us to fast-track potential new therapies with less toxicity into clinical trials. The treatment options currently being discovered bring great promise for children who have not experienced positive results under the standard treatment protocol.

Unbound's mission is to walk with the poor and marginalized of the world.

Operation Breakthrough's mission is to help children who are living in poverty develop to their fullest potential by providing them a safe, loving, and educational environment. The Center also strives to support and empower the children's families through education, advocacy, referral services, and emergency aid.

Pajama Program's mission is to promote and support and comforting bedtime routine and healthy sleep for all children to help them thrive. Pajama Program provides new pajamas and storybooks, sleep health education, and caring connections to help make bedtime better for children facing adversity and their caregivers. Through innovative, nationwide programming and focused efforts in New York City, Atlanta, and metro-Detroit, Pajama Program makes a comforting bedtime routine and a good night's sleep more accessible. Pajama Program meets its mission with the help of a national network of volunteers, generous donors, and thousands of community-based organizations across the United States, including Puerto Rico. Since 2001, Pajama Program has delivered over 7.5 million Good Nights for Good Days.

HADASSAH, the Women's Zionist Organization of America, is a volunteer women's organization whose members are motivated and inspired to strengthen their partnership with Israel, ensure Jewish continuity, and realize their potential as a dynamic force in American society. Founded in 1912, Hadassah retains the passion and timeless values of its founder, Henrietta Szold, Jewish scholar and activist, who was dedicated to Judaism, Zionism, and the American ideal. Committed to the centrality of Israel based on the renaissance of the Jewish people in its historic homeland, Hadassah promotes the unity of the Jewish people. In Israel, Hadassah initiates and supports pace-setting health care, education and youth institutions, and land development to meet the country's changing needs. In the United States, Hadassah enhances the quality of American and Jewish life through its education and Zionist youth programs, promotes health awareness, and provides personal enrichment and growth for its members.

American Jewish World Service is the leading Jewish organization working to fight poverty and pursue justice in Africa, Asia, Latin America and the Caribbean. Through philanthropy and advocacy, we respond to the most pressing issues of our time—from disasters, genocide and hunger to the persecution of women and minorities worldwide. With Jewish values and a global reach, AJWS is making a difference in millions of lives and building a more just and equitable world.

The Foundation's mission is to raise funds that advance scientific research into the causes, treatments and prevention of ALS; provide people living with ALS, their families and caregivers exceptional clinical care and support services; and increase awareness and eduction of ALS.

Huntsman Cancer Institute’s mission is to understand cancer from its beginnings, to use that knowledge in the creation and improvement of cancer treatments, to relieve the suffering of cancer patients, and to provide education about cancer risk, prevention, and care.

The mission of Casting for Recovery (CfR) is to enhance the quality of life of women with breast cancer through a unique program that combines breast cancer education and peer support with the therapeutic sport of fly fishing. The retreats offer opportunities for women to find inspiration, discover renewed energy for life and experience healing connections with other women and nature. CfR’s retreats are open to breast cancer survivors of all ages, in all stages of treatment and recovery, and are free to participants. On a physical level, the gentle, rhythmic motion of fly casting is similar to exercises often prescribed after surgery or radiation to promote soft tissue stretching. On an emotional level, women are given the opportunity to experience a new activity in a safe environment amongst a supportive group of peers. The retreats provide resources to help address quality of life issues after a breast cancer diagnosis, and a new outlet – fly fishing – as a reprieve from the everyday stresses and challenges of their cancer.

Every 13 minutes a woman dies from breast cancer. Each year in the United States alone, more than 275,000 women and hundreds of men are diagnosed with breast cancer, and more than 42,000 die from the disease. Another 3 million people are living with the disease. The National Breast Cancer Coalition Fund's mission is to end breast cancer by increasing federal funding for breast cancer research, creating access to breast and cervical cancer care for underserved and uninsured women, and training advocates to play an active role wherever breast cancer decisions are made.

Promises2Kids’ mission is to create a brighter future for foster children. From the moment they come into foster care and through to adulthood, Promises2Kids provides the hope, support, and opportunities these individuals need to change their lives for the better - now and for years to come.

Shoes That Fit tackles one of the most visible signs of poverty in America by giving children in need new athletic shoes to attend school with dignity and joy, prepared to learn, play and thrive. A new pair of shoes can be a life-changing event for a child. School attendance, self-esteem and behavior improve. Physical activity increases. Smiles return. All from an often over-looked item—a good pair of shoes. Our vision is that, one day, every child in America who needs new shoes gets new shoes, allowing all children the opportunity to reach their highest potential.